Healthspan Post

Healthspan Post

Healthspan Post

What the research on NAD+, NMN and healthy aging actually shows.

· Produced by an AI research system · How we work

NMN and exercise

Sample: does NMN improve energy, exercise and recovery? What the human trials show

NMN reliably raises blood NAD+. Endurance shows the clearest signal; strength, muscle and recovery claims mostly do not hold up in people.

· Sample

Grade A · 9Grade B · 4Grade C · 1

Evidence map: each dot is a study14 studies plotted by publication year (2018 to 2026) and number of people studied on a log scale. 13 of 14 studies are in humans. Gao 2026: meta-analysis, n 1,599, grade A. Liao 2021: RCT, n 48, grade A. Yi 2023: RCT, n 80, grade A. Prokopidis 2025: meta-analysis, n not reported, grade A. Kim 2022: RCT, n 108, grade A. Akasaka 2023: RCT, n 14, grade B. Pencina 2023: RCT, n 30, grade B. Yang 2026: RCT, n 11, grade B. Sun 2023: meta-analysis, n not reported, grade A. Das 2018: animal, n not reported, grade C, not human. Zhang 2025: meta-analysis, n 513, grade A. Wang 2025: meta-analysis, n 412, grade A. Gallagher 2026: systematic review, n not reported, grade A. Yoshino 2021: RCT, n not reported, grade B.Gao 2026: meta-analysis, n 1,599, grade ALiao 2021: RCT, n 48, grade AYi 2023: RCT, n 80, grade AProkopidis 2025: meta-analysis, n not reported, grade AKim 2022: RCT, n 108, grade AAkasaka 2023: RCT, n 14, grade BPencina 2023: RCT, n 30, grade BYang 2026: RCT, n 11, grade BSun 2023: meta-analysis, n not reported, grade ADas 2018: animal, n not reported, grade C (not human)Zhang 2025: meta-analysis, n 513, grade AWang 2025: meta-analysis, n 412, grade AGallagher 2026: systematic review, n not reported, grade AYoshino 2021: RCT, n not reported, grade B
Each dot is a study: year × people studied. Color = evidence grade.

How we work

  1. Research. Every claim is tied to a paper indexed in PubMed.
  2. Grade. A for human trials and meta-analyses, B for small or pilot human studies, C for animal or cell work.
  3. Check. Software and a second AI model test each claim against its source before anything is published.

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